patA [2017-05-16 14:07:15]

aminotransferase

locus: BSU14000

pI: 6.01

mw: 43.29 kDa

protein length: 392 aa

gene length: 1176 bp

function: biosynthesis of lysine and peptidoglycan

product: aminotransferase

essential: yes

ec: 2.6.1.-

synonyms: uat

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan]
• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.6|Biosynthesis/ acquisition of lysine/ threonine]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

Gene

Coordinates: 1,471,857 → 1,473,038

Phenotypes of a mutant

• essential [Pubmed|23109554]

The protein

Catalyzed reaction/ biological activity

• N-acetyl-2-amino-6-ketopimelate -→ N-acetyl-L,L-2,6-diaminopimelate [Pubmed|24261876]

Protein family

• class-I pyridoxal-phosphate-dependent aminotransferase family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|62A9CD9AF72D0A48EC5ABC1585E2D8636D36D021|AlaT] (45%)

Structure

• [PDB|1GDE] (from Pyrococcus sp., 42% identity)

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• genes: [gene|094AE3AC8DFAFC8048ADAAB34F76DF2562D80CE7|patA]
  description: [Pubmed|22383849]

• genes: [gene|5B177CBC33203B5B2DA841097CEB29B3A3C37C08|ykzT]-[gene|094AE3AC8DFAFC8048ADAAB34F76DF2562D80CE7|patA]
  description: [Pubmed|22383849]

References

• 24261876,23109554